| 新世纪流感大流行的思考 |
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| 引用本文： | 王革非,李康生. 新世纪流感大流行的思考[J]. 生物化学与生物物理进展, 2009, 36(8): 945-949. DOI: 10.3724/SP.J.1206.2009.00382 |
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| 作者姓名： | 王革非 李康生 |
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| 作者单位： | 汕头大学医学院微生物学与免疫学教研室,广东高校免疫病理重点实验室,汕头,515041 |
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| 基金项目： | 国家自然科学基金(30571674，30771988)，广东省自然科学基金(05008347，8151503102000022)，广东高校优秀青年创新人才培育项目(LYM08056)，农业微生物学重点实验室开放课题(AML200910)和汕头大学医学院科研基金资助项目. |
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| 摘 要： | 2009年从墨西哥开始暴发了一场席卷全世界的流感疫情．此次大流行的毒株，甲型H1N1病毒，包含了猪源、禽源和人源流感病毒的基因片段．研究该毒株的基因重配、进化历程及其生物学特性，将对防控此次流行具有重要意义．目前，该毒株的遗传进化关系已明确，通过遗传性状分析可获知该毒株可能的生物学性状，但流感大流行动向、毒株遗传变化、毒力及致病性变化仍在密切监控中．流感病毒生态系统具有复杂性，其基因组易突变、易重配、易在自然宿主保存，使得流感大流行存在一定的必然性．正视流感大流行的威胁，积极提高流感病毒在生态系统中的监控，加强流行病学调查，发展疫苗与药物，建立有效公共卫生保障体系，才能降低流感大流行的破坏性．
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| 关 键 词： | 流感病毒，甲型H1N1，流感大流行，基因重配 |
| 收稿时间： | 2009-06-22 |
| 修稿时间： | 2009-07-07 |
Origins and views of the 2009 A/H1N1 influenza pandemic |
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| WANG Ge-Fei and LI Kang-Sheng. Origins and views of the 2009 A/H1N1 influenza pandemic[J]. Progress In Biochemistry and Biophysics, 2009, 36(8): 945-949. DOI: 10.3724/SP.J.1206.2009.00382 |
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| Authors: | WANG Ge-Fei and LI Kang-Sheng |
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| Affiliation: | Department of Microbiology and Immunology; The Key Immunopathology Laboratory of Guangdong Province,Shantou University Medical College, Shantou 515041, China;Department of Microbiology and Immunology; The Key Immunopathology Laboratory of Guangdong Province,Shantou University Medical College, Shantou 515041, China |
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| Abstract: | The pandemic outbreak of influenza has been started from Mexico in 2009 to 70 countries during 2 months. On 11th of June , WHO announced influenza pandemic alert level rose to the highest level 6, which means the first influenza pandemic in 21st century is coming. Till 6th of July, 94 512 confirmed cases from more than 120 countries and areas were reported, including 429 cases were died. The genetic fragment of swine, poultry sources and human influenza viruses are contained in this strain, A/H1N1 influenza... |
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| Keywords: | influenza virus A/H1N1 pandemic gene reassortment |
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