miR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151 |
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| Authors: | Xun Wang Honggang Yu Xinyao Lu Peng Zhang Minglin Wang Yikui Hu |
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| Affiliation: | 1. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China;2. Department of Gastroenterology, Wuchang Hospital of Wuhan City, Wuhan 430063, China;3. Department of Neurology, Pu Ai Hospital of Wuhan City, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430034, China |
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| Abstract: | Gastric cancer (GC) is the second common cause of cancer-related death worldwide. microRNAs (miRNAs) play important roles in the carcinogenesis of GC. Here, we found that miR-22 was significantly decreased in GC tissue samples and cell lines. Ectopic overexpression of miR-22 remarkably suppressed cell proliferation and colony formation of GC cells. Moreover, overexpression of miR-22 significantly suppressed migration and invasion of GC cells. CD151 was found to be a target of miR-22. Furthermore, overexpression of CD151 significantly attenuated the tumor suppressive effect of miR-22. Taken together, miR-22 might suppress GC cells growth and motility partially by inhibiting CD151. |
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| Keywords: | miR-22 Gastric cancer CD151 Proliferation Migration Invasion |
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