|
|||||
|
|
High glucose modifies transient receptor potential canonical type 6 channels via increased oxidative stress and syndecan-4 in human podocytes |
|
| Authors: | Florian Thilo Marlene Lee Shengqiang Xia Andreas Zakrzewicz Martin Tepel |
| Institution: | 1. Experimental and Clinical Research Center, Charité, Berlin, Germany;2. Charité Berlin, Shear Stress and Vascular Biology Research Group, Institute of Physiology, Berlin, Germany;3. Odense University Hospital, Department of Nephrology, University of Southern Denmark, Institute for Molecular Medicine, Cardiovascular and Renal Research, Institute of Clinical Research, Odense, Denmark;4. Department of Urology, Tenth People’s Hospital, Tongji University of Shanghai, PR China |
| Abstract: | Transient receptor potential canonical (TRPC) channels type 6 play an important role in the function of human podocytes. Diabetic nephropathy is characterized by altered TRPC6 expression and functions of podocytes. Thus, we hypothesized that high glucose modifies TRPC6 channels via increased oxidative stress and syndecan-4 (SDC-4) in human podocytes. |
| Keywords: | Diabetic nephropathy Podocytes Transient receptor potential channels Syndecan-4 High glucose Oxidative stress |
| 本文献已被 ScienceDirect 等数据库收录！ | |