P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth |
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Authors: | Jun Zhou Songhua ZhanWenli Tan Ruixin ChengHangjun Gong Qiong Zhu |
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Institution: | Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China |
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Abstract: | MTA2 is a member of metastasis associated family, which is highly expressed in several solid tumors and associated with tumor cells migration and invasion. Here, we report that MTA2 is acetylated at K152 and histone acetyltransferase p300 binds to and acetylates MTA2. Furthermore, mutation of the MTA2 acetylation site inhibits the growth of colorectal cancer cells and migration and invasion of Rat1 fibroblasts. These results reveal a novel post-translational regulation of MTA2 by the way of p300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research. |
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Keywords: | MTA2 P300 Acetylation Cell growth Migration |
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