HepG2.2.15 as a model for studying cell protrusion and migration regulated by S100 proteins |
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| Authors: | Shiying Liu Rui Zhou Jian Zhong Chunlai Nie Zhu Yuan Liangxue Zhou Na Luo Chunting Wang Aiping Tong |
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| Affiliation: | 1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China;2. Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, PR China;3. Nankai University School of Medicine, Tianjin, PR China |
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| Abstract: | Much of the difficulty in elucidating the precise function of S100 protein family has been attributed to functional redundancy and compensation by its conserved family members. In this study, we showed that seven S100 family members were almost totally undetectable in HepG2.2.15 cells, while all of them were highly expressed in its parental HepG2 cells. Re-expression of S100 proteins in HepG2.2.15 cells can partially rescue their defects in cell protrusion and migration through the regulation of cytoskeletons and adhesions. Thus, HepG2.2.15 can serve as a useful model for studying cell protrusion and migration regulated by S100 proteins. |
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| Keywords: | Cytoskeleton Cell protrusion Cell migration S100 proteins Hepg2.2.15 cells |
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