Aquaporin-4 as a molecular partner of cystic fibrosis transmembrane conductance regulator in rat Sertoli cells |
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| Authors: | Tito T. Jesus,Raquel L. Bernardino,Ana D. Martins,Rosá lia Sá ,Má rio Sousa,Marco G. Alves,Pedro F. Oliveira |
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| Affiliation: | 1. CICS – UBI – Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal;2. Department of Microscopy, Laboratory of Cell Biology & Multidisciplinary Unit for Biomedical Research, UMIB-FCT, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal;3. Centre for Reproductive Genetics Alberto Barros, Porto, Portugal |
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| Abstract: | Sertoli cells (SCs) form the blood–testis barrier (BTB) that controls the microenvironment where the germ cells develop. The cystic fibrosis transmembrane conductance regulator (CFTR) plays an essential role to male fertility and it was recently suggested that it may promote water transport. Interestingly, Aquaporin-4 (AQP4) is widely expressed in blood barriers, but was never identified in SCs. Herein we hypothesized that SCs express CFTR and AQP4 and that they can physically interact. |
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| Keywords: | CFTR Aquaporin-4 Sertoli cells Water transport |
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