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Fatty acid epoxyisoprostane E2 stimulates an oxidative stress response in endothelial cells
Authors:Xinmin Yan  Sangderk Lee  B. Gabriel Gugiu  Lukasz Koroniak  Michael E. Jung  Judith Berliner  Jinluo Cheng  Rongsong Li
Affiliation:1. Changzhou No. 2 People’s Hospital, Diabetes Institute, 29 Xinglong Lane, Changzhou City, Jiangsu Prov. 213003, China;2. Department of Medicine, University of California, Los Angeles, 650 Charles Young Dr., Los Angeles, CA 90095, USA;3. Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;4. Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, CA 90095, USA;5. Department of Biomedical Engineering, University of Southern California Los Angeles, CA 90089, USA
Abstract:
Keywords:EI, epoxyisoprostane E2   OxPL, oxidized phospholipids   OxPAPC, oxidized 1-palmitoyl-2-arachidonoyl-sn-Glycero-3-phosphorylcholine   PEIPC, 1-palmitoyl-2-epoxyisoprostane E2-sn-glycero-3-phosphorylcholine   POVPC, 1-palmitoyl-2-oxovaleroyl-sn-glycero-3-phosphorylcholine   PGPC, 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine   PUFA, polyunsaturated fatty acids   PLA2, Phospholipase A2   HETE, hydroxyeicosatetraenoic acid   HODE, hydroxyoctadecadienoic acids   HDL, high density lipoprotein   HAEC, human aortic endothelial cells   ROS, reactive oxygen species   Nox, NADPH oxidase   Nrf2, nuclear factor E2-related factor   ARE, antioxidant response element   HO-1, heme oxygenase-1   NAC, N-acetyl cysteine
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