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Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses |
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| Authors: | Heli Venhoranta Shun Li Sylwia Salamon Tatiana Flisikowska Magnus Andersson Marek Switonski Alexander Kind Angelika Schnieke Krzysztof Flisikowski |
| Affiliation: | 1. Department of Production Animal Medicine, University of Helsinki, Saarentaus, Finland;2. Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany;3. Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637 Poznan, Poland |
| Abstract: | The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3′ end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain. |
| Keywords: | Non-CpG methylation Epigenetic regulation Intrauterine growth restriction PEG3 Mammalian DNA |
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