Mineralocorticoid receptor function in bone metabolism and its role in glucocorticoid-induced osteopenia |
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Authors: | Toshio Fumoto,Kiyo-aki Ishii,Masako Ito,Stefan Berger,Gü nther Schü tz,Kyoji Ikeda |
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Affiliation: | 1. Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan;2. Medical Work-Life-Balance Center, Nagasaki University Hospital, Nagasaki 852-8501, Japan;3. Department of Molecular Biology of the Cell I, German Cancer Center, Heidelberg, Germany |
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Abstract: | Although the mineralocorticoid receptor (MR) is expressed in osteoblasts and osteocytes and frequently co-localizes with the glucocorticoid receptors (GR), its pathophysiological functions in bone remain elusive. We report here that pharmacologic inhibition of MR function with eplerenone resulted in increased bone mass, with stimulation of bone formation and suppression of resorption, while specific genetic deletion of MR in osteoblast lineage cells had no effect. Further, treatment with eplerenone as well as specific deletion of MR in osteocytes ameliorated the cortical bone thinning caused by slow-release prednisolone pellets. Thus, MR may be involved in the deleterious effects of glucocorticoid excess on cortical bone. |
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Keywords: | Mineralocorticoid receptor Glucocorticoid Eplerenone Osteoporosis |
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