Stimulation of megakaryocytic spleen colonies in mice by thrombopoietin. |
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Authors: | T P McDonald M Cottrell C C Congdon O Walasek G H Barlow |
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Institution: | 1. University of Tennessee Memorial Research Center Center for the Health Sciences 1924 Alcoa Highway, Knoxville, Tennessee 37920, USA;7. Abbott Laboratories, North Chicago, Illinois 60064, USA |
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Abstract: | Kidney cell culture medium that was shown to stimulate thrombocytopoiesis in TSF assay mice was injected into lethally-irradiated, bone marrow transplanted mice. Results showed that the injection of TSF-rich material caused an increase in the number of megakaryocytic colonies when compared to control mice. The numbers of surface colonies and colonies/spleen section were not altered by TSF treatment. Erythroid, granulocytic, and undifferentiated colonies were not elevated by TSF injection. These data support the hypothesis that kidney cells in culture produce a humoral factor that controls the regulation of platelet and megakaryocyte production. |
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