Expression of human leukocyte antigen G is associated with prognosis in nasopharyngeal carcinoma |
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Authors: | Cai Man-Bo Han Hui-Qiong Bei Jin-Xin Liu Chao-Chun Lei Jin-Ju Cui Qian Feng Qi-Sheng Wang Hai-Yun Zhang Jia-Xing Liang Yi Chen Li-Zhen Kang Tie-Bang Shao Jian-Yong Zeng Yi-Xin |
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Institution: | State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China. |
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Abstract: | Human leukocyte antigen G (HLA-G) has multiple immune regulatory functions including the induction of immune tolerance in malignancies. The roles of HLA-G have not been investigated in nasopharyngeal carcinoma (NPC). This study is aimed to evaluate the role of HLA-G as prognostic factor for NPC patients as well as its role in the immune regulation. Western assays showed high HLA-G expression in NPC cell lines, but low in the immortalized nasopharyngeal epithelial cell line NP69. HLA-G protein was further detected in 79.2% of 552 NPC specimens with immunohistochemistry (IHC), but not in normal nasopharyngeal epithelium tissue. Moreover, high expression of HLA-G predicted poor survival of NPC patients and positively correlated with tumor N classification and recurrence or metastasis. Multivariate analysis indicated that HLA-G was an independent and unfavorable prognostic factor. Furthermore, the presence of CD68+ macrophages and IL-10 were also examined, which are two prognostic markers of NPC and important factors for regulating immune surveillance. The correlations of HLA-G with these two immune factors were revealed in NPC tissues. Taken together, our results suggest that HLA-G is an independent biomarker for NPC prognosis, and HLA-G might contribute to NPC progression, which might jointly regulate immune surveillance in NPC together with macrophages and IL-10. |
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Keywords: | Nasopharyngeal carcinoma HLA-G Prognosis IL-10 macrophage |
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