Metabolism of benzo(a)pyrene by human lung microsomal fractions |
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Authors: | R A Prough Z Sípal S W Jakobsson |
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Affiliation: | 1. Department of Biochemistry, The University of Texas Health Science Center, 5323 Harry Hines Blvd., Dallas, Texas 75235, USA;1. Department of Forensic Medicine, Karolinska Institutet, S-104 01, Stockholm, Sweden |
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Abstract: | The metabolism of benzo(a)pyrene was studied using microsomal fractions obtained from human lung derived at either resection or autopsy. The rates of metabolism and metabolite distribution were monitored using high pressure liquid chromatography and the metabolic rates were noted to be similar to those obtained using rat lung microsomes. In contrast to the rat, human lung microsomes appear to form a higher percentage of the 7,8-dihydro-7, 8-diol or 9,10-dihydro-9, 10-diol of benzo(a)pyrene as a fraction of the total metabolites. However, there was a significant variation among the human lung microsomal preparations which might reflect the clinical diagnosis and/or individual variation. |
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