Evolution of the diverse antifreeze proteins |
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Authors: | Chi-Hing C Cheng |
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Affiliation: | Department of Molecular and Integrative Physiology, University of Illinois, 407 S. Goodwin, Urbana, Illinois 61801, USA |
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Abstract: | Different types of ice-growth-inhibiting antifreeze proteins, first recognized in fish, have now been isolated from insects and plants, and the list continues to expand. Their structures are amazingly diverse; how they attain the same function are subjects of intense research. Evolutionary precursors of several members have been identified — divergent proteins of apparently unrelated function. The hybridization of information from structural and molecular evolution studies of these molecules provides a forum in which issues of selection, gene genealogy, adaptive evolution, and invention of a novel function can be coherently addressed. |
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Keywords: | Abbreviations: AFGP antifreeze glycoprotein AFP antifreeze protein CRD carbohydrate-recognition domain LS-AFP longhorn sculpin AFP Mya million years ago PR pathogenesis related |
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