Recent progress in identifying genes regulating hematopoietic stem cell function and fate |
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| Authors: | Craig T Jordan Gary Van Zant |
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| Affiliation: | Blood and Marrow Transplantation Program, Markey Cancer Center, 800 Rose Street Room CC405, University of Kentucky Medical Center, Lexington, KY 40536, USA |
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| Abstract: | Significant advances in the use of genetic and molecular biology strategies have recently begun to identify genes that have a major impact on the determination, commitment and developmental potential of hematopoietic stem cells. Using a variety of experimental strategies, genes such as SCL, GATA-2, HoxB4, Flk-2, c-mpl, dlk, and others have been implicated as important regulators of stem cell growth. In addition, genetic mapping has identified several loci that correlate strongly with stem cell numbers and proliferation. |
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| Keywords: | Abbreviations: CAFC cobblestone area forming cells dlk delta-like ES cells embryonic stem cells FL Flk2/Flt3 ligand LTC-IC long-term culture-initiating cells Scfr stem cell frequency loci SCL stem cell leukemia TPO thrombopoietin |
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