The adenylyl and guanylyl cyclase superfamily |
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| Authors: | James H Hurley |
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| Institution: | Laboratory of Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA |
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| Abstract: | New structures solved in 1997 revealed that the adenylyl cyclase core consists of a pair of catalytic domains arranged in a wreath. Homologous catalytic domains are arranged in diverse adenylyl and guanylyl cyclases as symmetric homodimers or pseudosymmetric heterodimers. The kinship of the adenylyl and guanylyl cyclases has been confirmed by the structure-based interconversion of their nucleotide specificities. Catalysis is activated when two metal-binding aspartate residues on one domain are juxtaposed with a key aspargine—arginine pair on the other. Allosteric activators of mammalian adenylyl cyclase, forskolin and the stimulatory G protein α subunit, promote the catalytically optimal juxtaposition of the two domains. |
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| Keywords: | Abbreviations: AC adenylyl cyclase cAMP 3' 5' cyclic adenosine monophosphate Gβγ G protein β and γ subunits GC guanylyl cyclase Giα inhibitory G protein α subunit Gsα stimulatory G protein α subunit sGC soluble GC |
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