Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junction |
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Authors: | Marisa Ionta Raphael Adolpho Sant'ana Ferreira Sandra Cristina Pfister Gláucia Maria Machado-Santelli |
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Institution: | (1) Department of Cell and Developmental Biology, Institute of Biomedical Science University of Sao Paulo, Brazil;(2) Av. Prof. Lineu Prestes, 1524, ICB I, Sao Paulo, SP – Brazil, 05508-901 |
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Abstract: | Background Gap junction intercellular communication (GJIC) is considered to play a role in the regulation of homeostasis because it regulates
important processes, such as cell proliferation and cell differentiation. A reduced or lost GJIC capacity has been observed
in solid tumors and studies have demonstrated that GJIC restoration in tumor cells contribute to reversion of the transformed
phenotype. This observation supports the idea that restoration of the functional channel is essential in this process. However,
in the last years, reports have proposed that just the increase in the expression of specific connexins can contribute to
reversion of the malign phenotype in some tumor cells. In the present work, we studied the effects of exogenous Connexin 43
(Cx43) expression on the proliferative behavior and phenotype of rat hepatocarcinoma cells. |
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