Written in bone: young bone makes young blood |
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Authors: | Karin Gustafsson David T Scadden Karin Gustafsson David T Scadden |
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Institution: | Harvard Stem Cell Institute, Cambridge, MA, USA |
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Abstract: | Ageing of bone marrow haematopoietic stem cells has been mostly associated with cell-intrinsic mechanisms. New findings published in The EMBO Journal now show that reduced levels of the secreted matrix protein osteopontin in old bone marrow stroma cause ageing-associated features in HSCs. In line, old HSCs are functionally rejuvenated by interaction with protease-cleaved osteopontin fragment, and perform like young blood stem cells in vivo. |
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