Calcium dependent ATP losses in intact red blood cells without cellular accumulations of calcium |
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| Authors: | Gordon A Plishker Hillel J Gitelman |
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| Institution: | (1) Department of Medicine, University of North Carolina, School of Medicine, 27514 Chapel Hill, N.C.;(2) Department of Neurology, Neurosensory Center, Baylor College of Medicine, 6501 Fanin St., 77030 Houston, Texas |
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| Abstract: | Summary Intact human red blood cells incubated with ionophore A23187 and calcium develop a depletion of ATP that is dependent upon the concentrations of both A23187 and Ca. Incubations of fresh cells with 0.5  m A23187 and concentrations of Ca at or below 70 m produce a depletion of ATP without a net cellular uptake of Ca. In contrast, ATP-depleted cells display an ionophore-dependent cellular uptake of Ca, under identical conditions. A hypothesis is proposed that relates these ionophore-produced ATP depletions to active Ca extrusion by the Ca ATPase. |
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