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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection |
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| Authors: | Dooseop Kim Liping Wang Charles G. Caldwell Ping Chen Paul E. Finke Bryan Oates Malcolm MacCoss Sander G. Mills Lorraine Malkowitz Sandra L. Gould Julie A. DeMartino Martin S. Springer Daria Hazuda Michael Miller Joseph Kessler Renee Danzeisen Gwen Carver Anthony Carella Karen Holmes Janet Lineberger William A. Schleif Emilio A. Emini |
| Affiliation: | a Department of Medicinal Chemistry, Merck Research Laboratories, RY 121-240, PO Box 2000, Rahway, NJ 07065, USA b Department of Immunology Research, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA c Department of Antiviral Research, Merck Research Laboratories, West Point, PA 19486, USA |
| Abstract: | A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described. |
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