Predicting phenotypic traits of prokaryotes from protein domain frequencies |
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Authors: | Thomas Lingner Stefanie Mühlhausen Toni Gabaldón Cedric Notredame Peter Meinicke |
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Institution: | 1.Department of Bioinformatics, Institute of Microbiology and Genetics,Georg-August-University G?ttingen,Germany;2.Bioinformatics Program,Centre for Genomic Regulation (CRG),Barcelona,Spain |
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Abstract: | Background Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains
largely unsolved. Accurately predicting microbial phenotypes solely based on genomic features will allow us to infer relevant
phenotypic characteristics when the availability of a genome sequence precedes experimental characterization, a scenario that
is favored by the advent of novel high-throughput and single cell sequencing techniques. |
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Keywords: | |
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