Effect of Treadmill Exercise on Serotonin Immunoreactivity in Medullary Raphe Nuclei and Spinal Cord Following Sciatic Nerve Transection in Rats |
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Authors: | Arthiese Korb Leandro Viçosa Bonetti Sandro Antunes da Silva Simone Marcuzzo Jocemar Ilha Mariane Bertagnolli Wania Aparecida Partata Maria Cristina Faccioni-Heuser |
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Institution: | 1.Programa de Pós-Gradua??o em Neurociências, Instituto de Ciências Básicas da Saúde,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil;2.Departamento de Ciências Morfológicas,Instituto de Ciências Básicas da Saúde, UFRGS,Porto Alegre,Brazil;3.Departamento de Fisiologia,Instituto de Ciências Básicas da Saúde, UFRGS,Porto Alegre,Brazil |
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Abstract: | The serotoninergic system modulates nociceptive and locomotor spinal cord circuits. Exercise improves motor function and changes
dopaminergic, noradrenergic, and serotonergic central systems. However, the direct relationship between serotonin, peripheral
nerve lesion and aerobic treadmill exercise has not been studied. Using immunohistochemistry and optic densitometry, this
study showed that the sciatic nerve transection increased the serotoninergic immunoreactivity in neuronal cytoplasm of the
magnus raphe nuclei of trained and sedentary rats. In the dorsal raphe nucleus the increase only occurred in sedentary-sham-operated
rats. In the spinal cord of trained, transected rats, the ventral horn showed significant changes, while the change in dorsal
horn was insignificant. Von Frey’s test indicated analgesia in all exercise-trained rats. The sciatic nerve functional index
indicated recovery in the trained group. Thus, both the aerobic treadmill exercise training and the nervous lesion appear
to contribute to changes in serotonin immunoreactivity. |
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