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Genomic organization and gene expression of the multiple globins in Atlantic cod: conservation of globin-flanking genes in chordates infers the origin of the vertebrate globin clusters |
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| Authors: | Ola F Wetten Alexander J Nederbragt Robert C Wilson Kjetill S Jakobsen Rolf B Edvardsen Øivind Andersen |
| Institution: | 1.Department of Animal and Aquacultural Sciences,University of Life Sciences,Aas,Norway;2.Department of Natural Sciences and Technology,Hedmark University College,Bedriftsenteret,Hamar,Norway;3.Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biology,University of Oslo,Blindern,Oslo,Norway;4.Institute of Marine Research,Nordnes,Bergen,Norway;5.Nofima Marine,Aas,Norway |
| Abstract: | BackgroundThe vertebrate globin genes encoding the α- and β-subunits of the tetrameric hemoglobins are clustered at two unlinked loci. The highly conserved linear order of the genes flanking the hemoglobins provides a strong anchor for inferring common ancestry of the globin clusters. In fish, the number of α-β-linked globin genes varies considerably between different sublineages and seems to be related to prevailing physico-chemical conditions. Draft sequences of the Atlantic cod genome enabled us to determine the genomic organization of the globin repertoire in this marine species that copes with fluctuating environments of the temperate and Arctic regions. |
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