Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins |
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Authors: | Claire C Morgan Noeleen B Loughran Thomas A Walsh Alan J Harrison Mary J O'Connell |
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Institution: | (1) Bioinformatics and Molecular Evolution Group, School of Biotechnology, Dublin City University, 9 Glasnevin, Dublin, Ireland |
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Abstract: | Background Reproductive proteins are central to the continuation of all mammalian species. The evolution of these proteins has been greatly
influenced by environmental pressures induced by pathogens, rival sperm, sexual selection and sexual conflict. Positive selection
has been demonstrated in many of these proteins with particular focus on primate lineages. However, the mammalia are a diverse group in terms of mating habits, population sizes and germ line generation times. We have examined the selective
pressures at work on a number of novel reproductive proteins across a wide variety of mammalia. |
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