Coordination of Thiosemicarbazones and Bis(thiosemicarbazones) to Bismuth(III) as a Strategy for the Design of Metal-Based Antibacterial Agents |
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| Authors: | Josane A Lessa Débora C Reis Jeferson G Da Silva Lúcia T Paradizzi Nayane F da Silva Mariany de Fátima A Carvalho Sarah A Siqueira Heloisa Beraldo |
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| Institution: | Departamento de Química, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil, (phone: +55?31?3409?5740; fax: 55?31?3409?5700). |
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| Abstract: | Complexes Bi(2Fo4Ph)Cl(2) ] (1), Bi(2Ac4Ph)Cl(2) ] (2), Bi(2Bz4Ph)Cl(2) ] (3), Bi(H(2) Gy3DH)Cl(3) ] (4), Bi(H(2) Gy4Et)(OH)(2) Cl] (5), and Bi(H(2) Gy4Ph)Cl(3) ] (6) were prepared with pyridine-2-carbaldehyde 4-phenylthiosemicarbazone (H2Fo4Ph), 1-(pyridin-2-yl)ethanone 4-phenylthiosemicarbazone (H2Ac4Ph), phenyl(pyridin-2-yl)methanone 4-phenylthiosemicarbazone (H2Bz4Ph), as well as with glyoxaldehyde bis(thiosemicarbazone) (H(2) Gy4DH) and its 4-Et (H(2) Gy4Et) and 4-Ph (H(2) Gy4Ph) derivatives. The complexes exhibited antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Pseudomonas aeruginosa. Coordination to Bi(III) proved to be an effective strategy to increase the antibacterial activity of the thiosemicarbazones and bis(thiosemicarbazones). |
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