Polymorphism profile of nine short tandem repeat Loci in the Han chinese |
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| Authors: | Li Shuangding Yan Chunxia Deng Yajun Wang Ruilin Wang Jian Yang Huanming Li Shengbin |
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| Institution: | 1.Key Laboratory of National Ministry of Health for Forensic Sciences, Xi’an Jiaotong University, Xi’an 710061, China;2.Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China;3.Forensic Center in Beijing Genomics Institute, Beijing 101300, China |
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| Abstract: | Nine short tandem repeat (STR) markers (D3S1358, VWA, FGA, THO1, TPOX, CSFIPO, D5S818, D13S317, and D7S820) and a sex-identification marker (Amelogenin locus) were amplified with multiplex PCR and were genotyped with a four-color fluorescence method in samples from 174 unrelated Han individuals in North China. The allele frequencies, genotype frequencies, heterozygosity, probability of discrimination powers, probability of paternity exclusion and Hardy-Weinberg equilibrium expectations were determined. The results demonstrated that the genotypes at all these STR loci in Han population conform to Hardy-Weinberg equilibrium expectations. The combined discrimination power (DP) was 1.05 x 10(-10) within nine STR loci analyzed and the probability of paternity exclusion (EPP) was 0.9998. The results indicate that these nine STR loci and the Amelogenin locus are useful markers for human identification, paternity and maternity testing and sex determination in forensic sciences. |
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| Keywords: | short tandem repeats polymorphism Han population |
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