Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions

Authors:	Akritopoulou-Zanze Irini Wakefield Brian D Gasiecki Alan Kalvin Douglas Johnson Eric F Kovar Peter Djuric Stevan W

Affiliation:	Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA

Abstract:	We report the synthesis and biological evaluation of 5-substituted indazoles and amino indazoles as kinase inhibitors. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing [2+3] cycloaddition reactions and were evaluated against a panel of kinase assays. Potent inhibitors were identified for numerous kinases such as Rock2, Gsk3β, Aurora2 and Jak2.

Keywords:	Kinase scaffolds Kinase inhibitors Rock2 inhibitors Gsk3β inhibitors Aurora2 inhibitors Jak2 inhibitors [2+3] Cycloadditions Triazoles Isoxazoles
本文献已被 ScienceDirect PubMed 等数据库收录！