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| 乙肝病毒X蛋白结合蛋白最新研究进展 | |
| 引用本文： | 刘剑平,申杰,蓝文贤,龚福春. 乙肝病毒X蛋白结合蛋白最新研究进展[J]. 基因组学与应用生物学, 2012, 31(2): 192-196 |
| 作者姓名： | 刘剑平 申杰 蓝文贤 龚福春 |
| 作者单位： | 1. 长沙理工大学化学与生物工程学院,长沙,410114;中科院上海有机化学研究所生命有机国家重点实验室,上海,200032 2. 中科院上海有机化学研究所生命有机国家重点实验室,上海,200032 3. 长沙理工大学化学与生物工程学院,长沙,410114 |
| 基金项目： | 卫生部重大新药创制专项-重组蛋白和抗体库研制平台,科技部"蛋白质重大研究计划" |
| 摘 要： | 乙肝病毒X蛋白结合蛋白(HBXIP)是肝细胞癌变过程的一个关键因素,它能在动物肌肉组织和恶性肿瘤组织中过表达。近年来研究显示:HBXIP能与人体内多种蛋白结合。本文综述了HBXIP蛋白参与细胞凋亡与增殖、细胞周期进程、中心体复制、肿瘤细胞迁移等过程,以期为以HBXIP蛋白为靶标的新的抗乙肝病毒等药物设计提供基础。 |
| 关 键 词： | 乙肝病毒 乙肝病毒X蛋白结合蛋白 肿瘤 抗乙肝病毒药物 |
Latest Research Progress on the Hepatitis B X-interacting Protein (HBXIP) |
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| Liu Jianping , Shen Jie , Lan Wenxian , Gong Fuchun. Latest Research Progress on the Hepatitis B X-interacting Protein (HBXIP)[J]. Genomics and Applied Biology, 2012, 31(2): 192-196 | |
| Authors: | Liu Jianping Shen Jie Lan Wenxian Gong Fuchun |
| Affiliation: | 1* 1 College of Chemistry and Biochemical Engineering,Changsha University of Science and Technology,Changsha,410114;2 State Key Laboratory of Bio-organic and Natural Product Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,200032 * Corresponding author,gfc139@yahoo.com.cn DOI:10.3969/gab.031.000192 |
| Abstract: | The hepatitis B X-interacting protein(HBXIP) is a key factor in the process of canceration of liver cells,which can overexpress in animal muscle tissue and malignant tumors tissue.In recent years,studies have shown that HBXIP can bind a variety of proteins of the human body.In this review,we summarized the latest advances on the studies about how HBXIP is involved in cell apoptosis and proliferation,cell cycle progression,centrosome replication,and tumor cell migration through interaction with other proteins,in order to rationally design new anti-hepatitis B virus drug using HBXIP as a target in the future. |
| Keywords: | Hepatitis B virus Hepatitis B X-interacting protein(HBXIP) Tumor Anti-hepatitis B virus drug |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |