致病菌基因组岛的研究进展

细菌基因组岛是细菌基因组上的特定区域,和水平基因转移相关,具有一定的结构特点,常携带致病、耐药及与适应性等功能相关的基因。通过基因组岛在细菌间的移动,可以造成相关基因在细菌间的传播,在细菌生存和致病等过程中具有重要作用。目前已经可通过生物信息和分子生物学实验等方法对基因组岛进行预测和验证。通过对致病菌基因组岛的研究,可以阐释细菌致病性和耐药等重要功能的获得,对疾病进行溯源,在传染病预防控制中具有重要意义。

Progress in Research of Genomic Island in Pathogenic Bacteria

Bacterial genomic island is a specific region on the bacterial genome,which has certain structural features related to horizontal gene transfer and carries some functional genes related to pathogenicity,antibiotic resistance and adaptability.The genomic island plays important roles in the process of bacterial survival and pathogenicity due to its transfer that can cause pathogenic related genes spreading in bacteria.At present,genomic island can be predicted and validated through bioinformatics and molecular biological experiments.By studying the genomic islands in bacterial genome,we might explain how the bacteria acquire pathogenicity,drug resistance and other important functions,moreover trace the source of the disease.We believed that the research on genomic island has an important significance in preventing and controlling the infectious diseases.