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| miR-106-363基因簇在脊椎动物中的进化分析 | |
| 引用本文： | 龚熹,李思光,汪艳璐,罗玉萍.miR-106-363基因簇在脊椎动物中的进化分析[J].基因组学与应用生物学,2012,31(2):185-191. |
| 作者姓名： | 龚熹 李思光 汪艳璐 罗玉萍 |
| 作者单位： | 1. 南昌大学,食品科学与技术国家重点实验室,南昌,330047;南昌大学生命科学与食品工程学院,南昌,330031 2. 南昌大学,食品科学与技术国家重点实验室,南昌,330047 3. 南昌大学生命科学与食品工程学院,南昌,330031 |
| 基金项目： | 国家自然科学基金,江西省教育厅青年基金 |
| 摘 要： | microRNA(miRNA)是一类在真核生物体内广泛表达的非编码小分子RNA,在生物体生长、发育以及疾病发生等过程中都起着极其重要的作用。miR-106-363基因簇是一个高度保守的基因簇,编码miR-106、miR-18、miR-20、miR-19、miR-92和miR-363等6个miRNA。本文通过对miRBase数据库检索以及同源搜索的方法在16种脊椎动物中搜索到了miR-106-363基因簇。该miRNA基因簇在高等脊椎动物中高度保守,稳定存在。系统进化树分析表明,miR-106-363基因簇与miR-17-92基因簇有着共同的祖先,且在进化上miR-17-92基因簇有着更早的起源。 |
| 关 键 词： | microRNA(miRNA) miR-106-363基因簇 脊椎动物 进化分析 |
The Analysis of Evolution of miR-106-363 Gene Cluster in Vertebrate |
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| Gong Xi , Li Siguang , Wang Yanlu , Luo Yuping.The Analysis of Evolution of miR-106-363 Gene Cluster in Vertebrate[J].Genomics and Applied Biology,2012,31(2):185-191. | |
| Authors: | Gong Xi Li Siguang Wang Yanlu Luo Yuping |
| Institution: | 1* 1 State Key Laboratory of Food Science and Technology,Nanchang University,Nanchang,330047;2 College of Life Sciences and Food Engineering of Nanchang University,Nanchang,330031 * Corresponding author,luoyuping@163.com DOI:10.3969/gab.031.000185 |
| Abstract: | microRNA(miRNA),a kind of non-coding small RNA which diversely regulates gene expression in eukaryotic organism,has played an important role in the growth,development and disease processes of organism.miR-106-363 cluster,which encodes miR-106,miR-18,miR-20,miR-19,miR-92 and miR-363,is highly conserved.In this paper,by using miRBase database retrieval and homologous search,we found miR-106-363 gene cluster in sixteen vertebrates.miRNA gene cluster is highly conserved and stably exists in higher vertebrate.Phylogenetic tree analysis revealed that miR-106-363-gene cluster and miR-17-92 gene cluster have common ancestor,and miR-17-92 gene cluster originated earlier than miR-106-363 gene cluster. |
| Keywords: | microRNA(miRNA) miR-106-363 gene cluster Vertebrate Evolution analysis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |