High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis |
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Authors: | Liu Hong Jianjun Yang Yu Han Qun Lu Jun Cao Labiq Syed |
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Affiliation: | Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. |
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Abstract: | BackgroundMany microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival.MethodsA meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated.ResultsA total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% CI: 2.04–5.63, P < 0.05), which could significantly predict poorer survival.ConclusionsHigh expression of miR-210 might predict poor survival in patients with breast cancer. |
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Keywords: | CI, confidence interval HRs, hazard ratios miRNAs, microRNAs MOOSE, Meta-analysis of Observational Studies in Epidemiology group qRT-PCR, quantitative real-time PCR STS, soft-tissue sarcoma |
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