Thermodynamic studies on PNA and PNA/DNA dendrimer formation |
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Authors: | Moccia Maria Musumeci Domenica Valente Margherita Roviello Giovanni N Sapio Roberto Pedone Carlo Bucci Enrico M |
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Affiliation: | Dipartimento di Scienze Biologiche sez. Biostrutture, Università degli Studi di Napoli Federico II, Napoli, Italy. |
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Abstract: | In this work we report a kinetic and thermodynamic study relative to the formation of gel systems based on PNA and PNA/DNA dendrimers, useful for drug delivery or diagnostic applications. We realized two kinds of systems: a PNA-based monomolecular system formed by an autoassembling PNA tridendron (A) and a PNA/DNA bimolecular system based on a PNA tridendron with a mixed sequence and a DNA crosslinker (B). Both systems have the ability to form a three-dimensional network by means of specific W-C base pairing. |
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