Actin nucleation: Nucleation-promoting factors are not all equal |
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| Authors: | Henry N Higgs |
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| Affiliation: | Department of Biochemistry, 413 Vail Building, HB 7200, Dartmouth Medical School, Hanover, New Hampshire 03755-3844, USA. Henry.Higgs@Dartmouth.edu |
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| Abstract: | Arp2/3 complex plays a key role in regulated actin polymerization. A recent study has revealed marked differences in the ability of two nucleation-promoting factors - N-WASP and Scar/WAVE1 - to activate the Arp2/3 complex. Further insights have come from determination of the Arp2/3 crystal structure. |
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| Keywords: | Cell Biology Immunology Microbiology |
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