Partial amino acid sequences of mouse transplantation antigens

The partial N-terminal amino acid sequences of the K and D gene products from theH-2^q andH-2^s haplotypes are presented. These data in conjunction with data already published demonstrate striking homology relationships among the transplantation antigens of mouse and other species. Moreover, these new data support the presence of certain sequence patterns noted in earlier sequence studies (e. g. no Kness or Dness, species-associated residues, and complex allotypes). These patterns place interesting constraints on the genetic organization and evolutionary history of the genes encoding the transplantation antigens which are discussed in this report.Abbreviations used in this paper HEPES N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid - HPLC High performance liquid chromatograph(y) - MEM Minimum essential medium - PTH Phenylthiohydantoin - SDS Sodium dodecyl sulfate