Structural-functional study of glycine-and-proline-containing peptides (Glyprolines) as potential neuroprotectors |
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| Authors: | K. V. Martynova L. A. Andreeva P. A. Klimova Yu. G. Kirillova V. P. Shevchenko I. Yu. Nagaev S. I. Shram V. I. Shvets N. F. Myasoedov |
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| Affiliation: | (1) Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571, Russia;(2) Institute of Molecular Genetics, Russian Academy of Sciences, pl. akademika Kurchatova 46, D-182, Moscow, 123182, Russia |
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| Abstract: | A synthetic scheme for preparation of (Gly-Pro) n , (Pro-Gly) n (n = 2, 3), and (Pro-Gly-Pro) n (n = 1, 2) peptides was elaborated. The effect of the synthesized peptides and the Gly-Pro and Pro-Gly dipeptides on survival of cultured cells of PC12 rat pheochromocytoma was studied under the conditions of oxidative stress induced by brief incubation of the cells with hydrogen peroxide. Peptides of the general formula (Gly-Pro) n and the Pro-Gly-Pro peptide at a concentration of 0.2–100 μM were shown to decrease the number of damaged cells. The Gly-Pro peptide was the most active and decreased the number of damaged cells by 49% on average at a concentration of 100 μM. |
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| Keywords: | peptide synthesis glycine-and-proline-containing peptides oxidative stress necrosis the PC12 rat pheochromocytoma cell culture |
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