The major histocompatibility complex and human evolution |
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| Authors: | J Klein J Gutknecht N Fischer |
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| Affiliation: | Max-Planck Institut Für Biologie, Abteilung Immungenetik, Tübingen, FRG. |
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| Abstract: | Many alleles at the human major histocompatibility complex (HLA) loci diverged before the divergence of humans and great apes from a common ancestor. This fact puts a lower limit on the size of the bottleneck in human evolution: the genus Homo must have been founded by no less than ten and probably by more than 10,000 individuals. |
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