神经生长因子家族及其受体研究进展

过去几年在神经营养因子、受体和神经元细胞程序性死亡的研究领域中取得了几项引人注目的进展：（１）神经生长因子（ＮＧＦ）基因家族的其他一些成员包括脑源性神经营养因子（ＢＤＮＦ）、神经营养素－３（ＮＴ－３）、神经营养素－４（ＮＴ－４）、神经营养素－５（ＮＴ－５）的发现；（２）神经生长因子三维结构及功能和进化之关系的阐明；（３）定性了两种神经生长因子受体Ｐ７５＾ＮＧＦＲ和原癌基因ｐ１４０＾ｔｒｋＡ以及相关

Progress in the Study of Nerve Growth Factor Family and Its Receptors

There are several noticeable progress in the study of the neurotrophic factors,their receptors and the neuronal apoptosis. Firstly, several members of the nerve growth factor family have been identified: NGF, BDNF, NT-3 and NT-4/5.Secondly, the relationship between the three-dimensional structure of the NGF and its function and evolution has been revealed. Thirdly,two kinds of the neurotrophin family receptors were characterized, they are low- affinity NGFR(p75 NGFR)and the trk proto-oncogene product such as p140(trkA) , p145(trkB)and p145(trkC). Induction of apoptosis by the low-affinity NGFR was also found. Finaly it is possible to use the neurotrophin for treating the degenerative neurological illnesses.