脐带问充质干细胞联合表皮生长因子治疗III、Ⅳ期压疮的临床研究

目的：探讨脐带间充质干细胞移植联合表皮生长因子治疗III、Ⅳ期压疮的临床效果。方法：选取我院2011-2012年收治的III、Ⅳ期压疮患者143例为研究对象，随机分为对照组、实验一组和实验二组。对照组30例压疮患者行常规换药，实验一组58例压疮患者应用脐带间充质干细胞移植联合表皮生长因子治疗，实验二组55例压疮患者仅应用表皮生长因子治疗。治疗后，比较三组患者愈合时间及愈合效果。结果：实验一组和实验二组的显效时间和愈合时间均较对照组显著缩短，且实验一组的显效时间和愈合时间较实验二组更短，差异均有统计学意义（均P〈0．05）。实验一组的治愈率显著高于对照组（P〈0．05），而与实验二组比较无统计学差异（P〉0．05），实验二组的治愈率与对照组比较无统计学差异（P〈0．05）。实验一组的总有效率显著高于对照组和实验二组（P〈0．05），而实验二组的总有效率与对照组比较无统计学差异（P〉0．05）。结论：脐带间充质干细胞移植联合表皮生长因子较单用表皮生长因子及常规治疗方法更好的改善III、Ⅳ期压疮创面的愈合，避免患者组织感染，提高压疮患者的生活质量。

Clinical Research on the Umbilical Cord Mesenchymal Stem Cells Joint Epidermal Growth Factor in the Treatment of Stage III and IV Bedsore

Objective： To investigate the clinical efficacy of umbilical cord mesenchymal stem cell transplantation combined with epidermal growth factor in the treatment of stage III and IV bedsore. Methods： 143 cases with stage III and IV bedsore admitted in our hospital from 2011 to 2012 were selected and randomly divided into the control group, experimental group 1 and 2.30 cases in the con- trol group were given conventional treatment, 58 cases in the experimental group 1 were treated by umbilical cord mesenchymal stem cell transplantation combined with epidermal growth factor, while 55 cases in the experimental group 2 were treated by epidermal growth fac- tor alone. The healing time and healing effect were compared between two groups after treatment. Results： The effect initiating time and healing time of Experimental group 1 and 2 were significantly shortened than that of the control group （P〈0.05）, which was shorter in the Experimental group 1 than that in the Experimental group 2. The recovery rate of experiment group 1 was significantly higher than that of the control group（P〈0.05）, but no significant difference was found between the experiment group 1 and 2 as well as the experiment group 2 and control group （P〉0.05）. The total effective rates of experimental group 1 was significantly higher than those of the experimental group 2 and control group, while no significant difference was found between experiment group 2 and the control group （P〉0.05）. Conclusion： Umbilical cord mesenchymal stem cell transplantation combined with epidermal growth factor could more effectively accelerate the wound healing of bedsore, avoid tissue infection, improve the quality of life of patients with pressure ulcers than the treatment of epider- mal growth factor alone and conventional treatment.