不同抗生素序贯疗法治疗小儿支原体肺炎的临床分析

目的：探讨不同抗生素组合（红霉素＋阿奇霉素，阿奇霉素＋阿奇霉素）序贯治疗小儿支原体肺炎的临床疗效及其安全性。方法：将82例诊断为小儿支原体肺炎的患者分为红霉素＋阿奇霉素组（Erythromycin＋Azithromycin，E＋A组）和阿奇霉素＋阿奇霉素组（Azithromycin＋Azithromycin，A＋A组），E＋A组患者41例，先给予红霉素静滴治疗，后给予阿奇霉素口服治疗，A＋A组患者41例，先给予阿奇霉素静滴，后给予阿奇霉素口服治疗；治疗后观察和比较两组的l临床疗效、平均退热时间、用药疗程、住院时间及不良反应的发生率。结果：两组患者的临床疗效上比较无显著差异（P〉0．05）；但两组患者的用药时间（15．3±4．0VS17．9±5．4天）、平均退热时间（4．0±2．2VS5．2±2．4天）、平均住院时间（8．9±3．0Vs10．8±3．4天）均有显著性差异（P〈0．05）。两组不良反应的发生率比较无显著性差异（P〉0．05）。结论：红霉素静滴后给予阿奇霉素口服的序贯疗法治疗小儿支原体肺炎可显著缩短患者的疗程、退热时间和平均住院时间，值得临床推广。

Clinical Analysis of Different Antibiotics Sequential Therapy of Mycoplasma Pneumonia in Children

Objective： To explore the clinical effects of different combination of antibiotics sequential therapy （Erythromycin＋Azithromycin or Azithromycin＋Azithromycin） on mycoplasma pneumonia in children. Methods： 82 patients were divided into two groups randomly, i.e. Erythromycin＋Azithromycin group （E＋A group） and Azithromycin＋Azithromycin group （A＋A group）, there were 41 patients in each group. In the E＋A group, the patients were first given the Erythromycin infusion therapy, and then given the Azithromycin for oral take. In the A＋A group, the patients were first given Azithromycin infusion therapy and then the Azithromycin oral take. The clinical effects, medication time, hospitalize time, fever clearance time and the averse effects were analyzed and compared. Results： There was no significant difference of clinical effects between the two groups （P〉0.05）. But for the medication time （15.3± 4.0 VS. 17.9± 5.4, days, n=41）, hospitalize time （8.9± 3.0 VS. 10.8± 3.4, days, n=41） and the fever clearance time （4.0± 2.2 VS. 5.2± 2.4, days, n=41）, there were significant differences between the two groups （P〈0.05）. No significant difference of the incidence rates of adverse effects was found between the two groups（P〉0.05）. Conclusions： For the treatment of mycoplasma pneumonia in children, the Erythromycin＋Azithromycin sequential therapy was much more effective than the Azithromycin ＋ Azithromycin sequential therapy.