| Function and regulation of Aurora／Ipllp kinase family in cell division |
| |
| 引用本文： | Ke YW,Dou Z,Zhang J,Yao XB. Function and regulation of Aurora／Ipllp kinase family in cell division[J]. Cell research, 2003, 13(2): 69-81 |
| |
| 作者姓名： | Ke YW Dou Z Zhang J Yao XB |
| |
| 作者单位： | [1]LaboratoryforCellDynamics,SchoolofLifeSciences,UniversityofScienceandTechnologyofChina,Hefei230027,China [2]DepartmentofMolecularandCellBiology,UniversityofCalifornia,Berkeley,CA94720,USA |
| |
| 摘 要： | During mitosis,the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation,a complex movements orchestrated by mitotic kinases and its effector proteins.Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell.Defects in these processes can lead to aneuploidy or polyploidy.Aurora/Ipllp family, a class of conserved serine/threonine kinases,plays key roles in chromosome segregation and cytokinesis.This article highlights the function and regulation of Aurora/Ipllp family in mitosis and provides potential links between aberrant regulation of Aurora/Ipllp kinases and pathogenesis of human cancer.
|
| 关 键 词： | 细胞分裂 有丝分裂 激酶 功能 染色体 遗传物质 癌症 发病机理 亲本 分裂规律 |
Function and regulation of Aurora/Ipl1p kinase family in cell division |
| |
| Ke Yu Wen,Dou Zhen,Zhang Jie,Yao Xue Biao. Function and regulation of Aurora/Ipl1p kinase family in cell division[J]. Cell research, 2003, 13(2): 69-81 |
| |
| Authors: | Ke Yu Wen Dou Zhen Zhang Jie Yao Xue Biao |
| |
| Affiliation: | Laboratory for Cell Dynamics, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. |
| |
| Abstract: | During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipllp family in mitosis and provides potential links between aberrant regulation of Aurora/Ipllp kinases and pathogenesis of human cancer. |
| |
| Keywords: | Aurora (Ipllp) mitosis and cancer. |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
