Gene expression profile favoring phenotypic reversion: a clue for mechanism of tumor suppression by NF-IL6 3'UTR |
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| Authors: | DING GAN LIU QIU HONG JIANG YUN Yl WEI LI SUN BEI BEI FU Fu KUN ZHAO QIONG ZHOU ' State Key Laboratory of Molecular Biology Key Laboratory of Proteomics |
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| Affiliation: | DING GAN LIU,QIU HONG JIANG,YUN Yl WEI,LI SUN,BEI BEI FU,Fu KUN ZHAO,QIONG ZHOU ' State Key Laboratory of Molecular Biology and Key Laboratory of Proteomics,Institute of Biochemistryand Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai200031,China. E-mail: dgliu@sibs.ac.cn |
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| Abstract: | Transfection of cDNA in 3'untranslated region of human nuclear factor for interleukin-6 (NF-IL6 3'UTR) induced tumor suppression in a human hepatoma cell line. cDNA array analysis was used to reveal changes in gene expression profile leading to tumor suppression The results indicate that this suppression was not due to activation of dsRNA-dependent protein kinase, nor to inactivation of oncogenes; rather, all the changes in expression of known genes, induced by NF-IL6 3'UTR cDNA may be ascribed to the suppression of cellular malignancy. Therefore, our results imply that this 3'untranslated region may have played role of a regulator of gene expression profile. |
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| Keywords: | cDNA array NF-IL6 hepatoma 3 'UTR tumor suppression. |
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