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Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites
Authors:Mattie Floyd J  Stackpole Megan M  Stone Michelle C  Clippard Jessie R  Rudnick David A  Qiu Yijun  Tao Juan  Allender Dana L  Parmar Manpreet  Rolls Melissa M
Institution:Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Abstract:
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  • Highlights? Uniform microtubule polarity in dendrites requires directed microtubule growth ? Growing microtubule plus ends use stable microtubules as directional tracks ? Dendrite microtubule polarity is disrupted when kinesin-2 and +TIP levels are reduced ? Kinesin-2 attachment to microtubule plus ends might allow directed microtubule growth
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