Human population structure and the adaptive response to pathogen-induced selection pressures |
| |
| Authors: | Novembre John Han Eunjung |
| |
| Affiliation: | 1Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA;2Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, USA;3Department of Biostatistics, University of California, Los Angeles, CA, USA |
| |
| Abstract: | The past few years of research in human evolutionary genetics have provided novel insights and questions regarding how human adaptations to recent selective pressures have taken place. Here, we review the advances most relevant to understanding human evolution in response to pathogen-induced selective pressures. Key insights come from theoretical models of adaptive evolution, particularly those that consider spatially structured populations, and from empirical population genomic studies of adaptive evolution in humans. We also review the CCR5-Δ32 HIV resistance allele as a case study of pathogen resistance in humans. Taken together, the results make clear that the human response to pathogen-induced selection pressures depends on a complex interplay between the age of the pathogen, the genetic basis of potential resistance phenotypes, and how population structure impacts the adaptive process in humans. |
| |
| Keywords: | human adaptation pathogen resistance population structure CCR5-Δ32 |
| 本文献已被 PubMed 等数据库收录！ |
|
