Absolute stereochemistry of (+)-trans-1,2-dihydroxyacenaphthene,a mammalian metabolite of acenaphthylene |
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| Authors: | Mitsuru Imuta Masaji Kasai Herman Ziffer |
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| Affiliation: | Laboratory of Chemical Physics, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205 USA |
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| Abstract: | A sample of (+)-trans-1,2-dihydroxyacenaphthene, a mammalian metabolite of acenaphthylene, was prepared by stereoselective partial hydrolysis of the corresponding synthetic racemic diacetate using the mold, Rhizopus nigricans. The absolute stereochemistry of the trans-diol was established as (1R,2R) by conversion to the known dimethyl (2S,3S)diacetoxysuccinate. |
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| Keywords: | To whom correspondence should be addressed. |
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