| Abstract: | —Aqueous-soluble brain proteins from 100 adult humans have been screened by discontinuous polyacrylamide and by continuous-SDS-polyacrylamide electrophoresis for evidence of genetically determined variation. In addition 42 adult Macaca nemestrina and 36 inbred strains of mice were screened in the SDS-continuous system. No variation in position of major bands was found within species, although differences in relative intensity of staining were noted. Fetal human cerebral cortex gave profiles of aqueous-soluble proteins distinguishable from that of adults. After affinity chromatography on Concanavalin-A-agarose, adult samples gave one band on SDS-polyacrylamide gels, while fetal samples gave the same band plus an additional band, presumably representing glycoproteins. |
