Synthesis and anticancer activity of thiosemicarbazones |
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Authors: | Hu Wei-xiao Zhou Wei Xia Chun-nian Wen Xi |
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Affiliation: | College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310032, PR China. huyang@mail.hz.zj.cn |
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Abstract: | Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 microM. |
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