Poxviruses: Interfering with Interferon |
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| Institution: | 1. Department of Pathophysiology, West China School of Preclinical and Forrensic Medicine, Sichuan University, China;2. State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;3. School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, China;4. Department of Clinical Laboratory, Shanghai Public Health Clinical Center, Shanghai 201508, China;5. Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Medical School, Tongji University, Shanghai, China;6. Tuberculosis Clinic, Chaoyang Distric Center for Disease Control and Prevention, Chaoyang Distric, Beijing, China;1. Department of Cardiology, Patras University Hospital, Patras, Greece;2. Department of Cardiology, Attikon University Hospital, Athens, Greece;1. National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney, Level 6 Medical Foundation Building, 92-94 Parramatta Rd, Camperdown, NSW 2050, Australia;2. Royal Prince Alfred Hospital, Camperdown, NSW, Australia;3. St Vincent''s Hospital, Fitzroy VIC Australia;1. Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), Madrid, Spain;2. Centro Sandoval and Hospital Universitario Clínico de San Carlos, IdISSC, Madrid, Spain;3. Instituto de Investigación Germans Trias i Pujol, Badalona, Spain;4. Ciber de Enfermedades Infecciosas, Madrid, Spain;5. Instituto de Agroquímica y Tecnología de Alimentos, Valencia, Spain;6. Laboratorio de Arbovirus y Enfermedades Víricas Importadas, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain |
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| Abstract: | Interferon (IFN) is an important innate defense against virus infection and many viruses have consequently evolved ways to interfere with the action of IFN. The poxviruses are an excellent example and devote at least four proteins to this task. Two function within the infected cell to block the action of IFN-induced antiviral proteins, and two are secreted to capture type I and type II IFNs before they can bind to cellular IFN receptors. The vaccinia virus IFN receptors have a surprisingly broad species specificity that may aid virus replication in several species and provide clues about the enigmatic origin of vaccinia virus. |
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