Nitrendipine potentiates Bay k 8644-induced contraction of isolated porcine coronary artery: evidence for functionally distinct dihydropyridine receptor subtypes |
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| Authors: | G P Dube Y H Baik P L Vaghy A Schwartz |
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| Affiliation: | 1. School of life Science, Shanghai University, 99 Shangda Road,200444, China;2. Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;3. Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China;4. Department of General Surgery, Shanghai Ninth People''s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China;5. National Engineering laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, China;6. Chemistry Department, College of Science, Shanghai University, 99 Shangda Road,200444, China;7. Huaxia Eye Hospital of Foshan, Huaxia Eye Hospital Group, Foshan, Guangdong 528000, China |
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| Abstract: | Bay k 8644 and nitrendipine, dihydropyridines classified as calcium channel agonist and antagonist, respectively, produced concentration-dependent biphasic responses (contraction and relaxation) in porcine coronary artery rings. Nitrendipine relaxed rings (IC50 = 60 nM) that were contracted with 100 nM Bay k 8644. Pretreatment of rings with 60 nM nitrendipine caused paradoxical potentiation of Bay k 8644-induced contraction. The data are consistent with a model that consists of two functionally-distinct dihydropyridine "receptors" with which Bay k 8644 and nitrendipine interact as partial agonists. We propose that these excitatory and inhibitory dihydropyridine receptor subtypes mediate contraction and relaxation, respectively, by dihydropyridines. |
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