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Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex
Authors:de Graaf Petra  Zwart Wilbert T  van Dijken Remco A J  Deneka Magdalena  Schulz Thomas K F  Geijsen Niels  Coffer Paul J  Gadella Bart M  Verkleij Arie J  van der Sluijs Peter  van Bergen en Henegouwen Paul M P
Affiliation:Department of Molecular Cell Biology and Institute of Biomembranes, Utrecht University, The Netherlands.
Abstract:Phosphatidylinositol 4-kinasebeta (PI4Kbeta) plays an essential role in maintaining the structural integrity of the Golgi complex. In a search for PI4Kbeta-interacting proteins, we found that PI4Kbeta specifically interacts with the GTP-bound form of the small GTPase rab11. The PI4Kbeta-rab11 interaction is of functional significance because inhibition of rab11 binding to PI4Kbeta abolished the localization of rab11 to the Golgi complex and significantly inhibited transport of vesicular stomatitis virus G protein from the Golgi complex to the plasma membrane. We propose that a novel function of PI4Kbeta is to act as a docking protein for rab11 in the Golgi complex, which is important for biosynthetic membrane transport from the Golgi complex to the plasma membrane.
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