Studies of ent-kaurane diterpenes from Oyedaea verbesinoides for their inhibitory activity on vascular smooth muscle contraction |
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Authors: | Müller Stefan Tirapelli Carlos R de Oliveira Ana M Murillo Renato Castro Victor Merfort Irmgard |
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Institution: | Institute of Pharmaceutical Biology, University Freiburg, Stefan-Meier-Str. 19, 79104 Freiburg, Germany. |
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Abstract: | From the aerial parts of Oyedaea verbesinoides nine ent-kauranes and a sesquiterpene were isolated. ent-9alpha-Hydroxy-kaur-16-en-19-oic acid, ent-15beta-tigloyloxy-9alpha-hydroxy-kaur-16-en-19-oic acid, ent-15beta-angeloyloxy-9alpha-hydroxy-kaur-16-en-19-oic acid, ent-16alpha-hydroxykaurane and 1alpha-angeloyloxy-carotol are new for the genus or the species and ent-15beta-angeloyloxy-7alpha,9alpha-dihydroxy-kaur-16-en-19-oic acid is reported for the first time. Structure elucidation was based on one and two dimensional NMR as well as ESI and CI-MS analysis. Some diterpenes were proven to exhibit inhibitory effects on smooth muscle contraction on rat aorta. |
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Keywords: | Oyedaea verbesinoides ent-Kauranes Smooth muscle Rat aorta |
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