Mouse Offspring Derived from Fetal Ovaries or Reaggregates Which were Cultured and Transplanted into Adult Females |
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Authors: | Koichiro Hashimoto Motoko Noguchi Norio Nakatsuji |
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Affiliation: | Division of Developmental Biology, Meiji Institute of Health Science, 540 Naruda, Odawara 250, Japan;Department of Biology, Faculty of Science, Shizuoka University, Shizuoka 422, Japan |
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Abstract: | Primordial germ cells (PGCs) and gonia could be promising novel targets and vehicles for manipulation of the mammalian germ line. To make such manipulation a practical possibility, PGCs or gonia must be allowed to produce gametes and offspring after they were isolated from embryos and manipulated in culture. As the first step to develop such research strategy, we obtained offspring from mouse oogonia which were isolated from embryonic ovaries and cultured as dispersed cells before transplantation into female mice as reaggregates. |
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Keywords: | (mouse primordial germ cells oogonia ovary transplantation |
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